Frédéric Tangy, PhD, Dr.Sc., Project coordinator
Frédéric Tangy is Director of Research at CNRS (French National Centre for Scientific Research) and Head of Viral Genomics and Vaccination Research Unit at Institut Pasteur. He is a Member of the Scientific Council of Institut Pasteur and Director of the International Vaccinology course.
Frédéric Tangy has 25 years of research experience in the field of virology and vaccine development and, notably, developed the use of measles based vector for vaccination against other infectious diseases.
His Viral Genomics and Vaccination Research Unit has a large expertise in vaccination strategies, including molecular and cellular virology, immunology, animal models, and clinical trials. It also applies functional genomic approaches such as high-throughput cloning, yeast two-hybrid, mass-spectrometry, and NGS to study virus-host interactions.
Anastassia Komarova, PhD
Anastassia Komarova wrote her thesis on how functional elements within leader sequences of prokaryotic mRNAs affect prokaryotic translation initiation efficiency and held a post-doc position for research on regulation of eukaryotic translation initiation in a viral context.
Her research interests are developing and validation systems-level proteomic and riboproteomic approaches to study RNA-protein and protein-protein interactions during viral infection.
During the SAFE-Aqua project, she will work on:
- T1.3: Determine effects of classical PAMPs of vertebrates
- T3.4: Characterizing defective viral genomes produced by various penaeid shrimp viruses
- T3.5: Evaluation of defective viral genome-induced antiviral immunity in crustaceans
Sean Kennedy, PhD
Sean Kennedy holds a PhD in microbiology (University of Massachusetts) studying the sequence and genetic structure of Archaea.
Coming to France in 2005, he started a new NGS sequencing initiative, studying the intestinal microbiota and its link with obesity. Through his experience in high-throughput sequencing and data analysis, he served a critical role in the sequence and analysis of metagenomic data for the European projects MetaHIT (obesity, IBS, Crohn’s Disease), EvoTAR (antibiotic resistance in hospitals) and MetaCardis (cardiovascular disease and diabetes) as well as many project with industrial partners involved in allergies and childhood development and disease.
Currently, he is the Director of the Biomics Unit at the Pasteur Institute in Paris. Biomics is part of Pasteur’s new Center of Innovation and Technology (CITECH). The Unit, equipped with several high throughput Illumina instruments as well as a PacBio SEQUEL, offers collaboration and services for genomics, transcriptomics, metagenomics and genotyping project. In addition to offering sequencing of both DNA and RNA samples, the group also develops and provides access to a number of analysis pipelines for data analysis. The primary research activity of the group continues to focus on the microbiota and specifically the colonization of the intestine and its relationship with health and disease as mediated by the immune system and the environment.
His work on SAFE-Aqua will focus on:
- Tasks associated with WP6 (T6.2 and T6.3)
- Coordination with staff at BIOTEC on the first results of the project
- Organization of training associated with metagenomic analysis
- Explore additional funding opportunities.
Anavaj Sakuntabhai, M.D.
Anavaj Sakuntabhai has 10 years of experience in clinical medicine and holds a D. Phil. in Human molecular genetics (Oxford). He is a Senior scientist at Institut Pasteur works on developing a programme on the genetics on infectious diseases. He also Coordinated a European project on Dengue.
His Research interests focus on the significant role that T cell plays in protection against symptomatic dengue, which led to the new concept of next generation dengue vaccine.
His work on SAFE-Aqua will be on:
- T2.2: Genome assembly, data processing and bioinformatics analysis
- T2.3: Shrimp genome database
- T5.1: Determine transcriptomic gene expression in shrimp intestine upon exposure to pathogen using direct RNA sequencing approach
Maxime Chazal, M.Sc.
Maxime Chazal holds an M. Sc. In Biology and has 8 years of experience in research on cell-virus interaction.
He used to be a technician on HIV transmission mechanism between T-cells. Today his work includes: virus production, purification and titration, microscopy, molecular biology and preparation of sample for Next Generation Sequencing.
His research interest is innate immune response in cells infected with flavivirus (Yellow fever, Dengue, Zika viruses) and his work on SAFE-Aqua will be on:
- Understanding the Shrimp immunome (defective viral genome purification for penaeid shrimp virurses, sequencing analysis and functional tests.)
- Understanding the Host-microbe interactome (training on how to identify metabolites profiles high-resolution mass spectrometer)
Ségolène Gracias, B.Sc.
Ségolène Gracias holds a technician degree on bioanalyses and control and a B.Sc. in cell, tissue culture and molecular biology.
Her research work mostly focuses on mechanisms of innate immune response against vaccine and wild-type strain of Yellow fever in human hepatic cell lines. She also works on Dengue and Zika viruses.
In the SAFE-Aqua project, she will work on:
- testing shrimp antiviral immunity against virus in the presence of classical pathogen associated molecular patterns (PAMPs) of vertebrates and viral mimics.
- Understanding the shrimp immunome.
Alice Meignié, Ph.D. student
Alice Meigné already holds a B.Sc. in Chemistry and an M.Sc. In Molecular pharmacology (École Normale Supérieure). Her research focuses on the role of MV-C protein cell death pathways.
During the SAFE-Aqua project she will work on:
- Shrimp rearing and experimental trials under non- and a time-course pathogen exposure trials
- determining effects of feed additives to shrimp gut microbiota and survival rates under pathogen challenges
- Pathogen - P. monodon antibiosis: Hemocyte phagocytosis and cell death (apoptosis and ETosis)
Nolwenn Jouvenet, Ph.D.
Nolwenn Jouvenet holds a Ph.D. in Virology and her work included understanding intracellular transport of African swine fever virus and the mechanisms of assembly and budding of retroviruses, an important family of viruses that include HIV-1.
She is interested in virus-host interaction and innate immune response activation upon infection with several medically important viruses, including flaviviruses.
During the SAFE-Aqua project, she will help on data analysis and publication writing.
Richard Paul, D.Phil.
Richard Paul holds a D.Phil. in Molecular epidemiology from Oxford University. He is a Senior scientist and was hired to develop a programme on the transmission of infectious diseases
His work notably focuses on mechanisms of assembly and budding of retroviruses, an important family of viruses that include HIV-1.
He coordinated several research programmes in Africa and Asia on infectious and non-infectious diseases. His work focused on identifying the key role human genetics plays in underlying the human reservoir of infection and infectiousness and the impact non-infectiousness disease susceptibility has on infectious disease susceptibility
For SAFE-Aqua, he will work on genome assembly, data processing and bioinformatics analysis, a shrimp genome database, the first sequencing analysis of numerous defective interfering genomes of penaeid shrimp viruses and determining transcriptomic gene expression in shrimp intestine upon exposure to pathogen using direct RNA sequencing approach.
Maëlle Pichard– Project manager
Maëlle Pichard holds an M.A. in European Affairs and has several years of experience in European project writing and management. She’s been working at the Institut Pasteur for 3 years and has managed several projects with the Institut Pasteur as coordinator.
For the SAFE-Aqua project she will participate to secondments and work on Maximizing knowledge sharing and integrating knowledge and project management to ensure future project success and setting up effective management & communication structures, guidance and support.